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Image Search Results
Journal: medRxiv
Article Title: NMR metabolomic modelling of age and lifespan: a multi-cohort analysis
doi: 10.1101/2023.11.07.23298200
Figure Lengend Snippet: A) Associations with non-communicable disease risk factors. Estimates represent standard deviation change in metabolomic age associated with exposure which have been categorised into binary variables. B) Associations with age-related biomarkers. Estimates represent standard deviation (SD) change in metabolomic age associated with 1 SD unit change in biomarker levels. To avoid individuals from being accounted for more than once in the analysis, samples from YFS2001 and YFS2007, NFBC1966 (31y), and SABRE2 were excluded in the disease risk factor analysis, and subsequently up to 28,000 samples were included. C) Associations of metabolomic age models with adverse incident health events. Cox proportional regression models were adjusted for chronological age, sex, and ethnicity, and hazard ratios were estimated per unit of change in metabolomic age. 969, 638 and 715 deaths respectively in UKCTOCS, SABRE and WHII, and 1,273 and 442 coronary heart disease events, and 707 and 181 stroke events were respectively recorded in the UKCTOCS and SABRE cohorts during the subsequent follow-up period of up to 25 years. Analyses in A) – C) were based on cohort fixed effect inverse variance weighted meta-analyses and linear regression models adjusted for chronological age, sex and ethnicity. * denotes a P < 0.001 and error bars represent the lower and upper limits of the 95% confidence intervals.
Article Snippet: A high throughput 1 H
Techniques: Standard Deviation, Biomarker Assay
Journal: medRxiv
Article Title: NMR metabolomic modelling of age and lifespan: a multi-cohort analysis
doi: 10.1101/2023.11.07.23298200
Figure Lengend Snippet: A) Assessment of metabolomic ageing model scores in UK Biobank (N total = 101,524). Pearson’s correlation coefficients with chronological age are shown. B) Longitudinal assessment of metabolomic ageing model scores in UK Biobank. C) Associations of chronological age-adjusted metabolomic age scores with adverse incident events in the UK Biobank. Cox proportional regression models were adjusted for sex and chronological age. Hazard ratios were estimated based on per year of metabolomic age. * denotes a P < 0.001 and error bars represent the lower and upper limits of the 95% confidence intervals.
Article Snippet: A high throughput 1 H
Techniques: